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The synthesis of 1-aminodihydroisoquinolines by an imine addition-cyclisation reaction

✍ Scribed by Haydn Beaton; Peter Hamley; Alan C. Tinker

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 201 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)10736-5

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✦ Synopsis

A variety of l-amino-3,4-dihydroisoquinolines substituted at the 3-position and related thienopyridines were prepared by lithiation of ortho-methyl aromatic nitriles, addition to Ntrimethylsilylimines and spontaneous cyclisation.

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