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The synthesis of 1-14C-arachidonate and 3-14C-docosa-7,10,13,16-tetraenoate

โœ Scribed by Howard Sprecher


Book ID
112770383
Publisher
Springer-Verlag
Year
1971
Tongue
English
Weight
446 KB
Volume
6
Category
Article
ISSN
0024-4201

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Preparation of methyl [1-14C]docosa-7,10
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## Abstract Methyl [1โ€^14^C]docosaโ€7,10,13,16โ€tetraenoate was prepared from [1โ€^14^C]arachidonic acid by two successive Arndtโ€Eistert syntheses which also can be used for the stepโ€wise homologation of other labeled fatty acids. After purification by gas chromatography the specific activity was 6.16

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## Abstract Existing methods have been adapted for the small scale synthesis of the title compounds in high yield. Modification of the iodoform reaction enables 1,3โ€^14^Cโ€acetone (I) to be converted in over 95% yield to ^14^Cโ€iodoform (II) which is reduced by sodium aresenite to ^14^Cโ€methylene dii