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The synthesis and reactivity of alkyl-aminosubstitutedmethylenediphosphonates

✍ Scribed by Ding Quan Qian; Xiao Dong Shi; Ru Zhen Cao; Lun Zu Liu

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
153 KB
Volume
10
Category
Article
ISSN
1042-7163

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✦ Synopsis

Reactions of diethyl phosphite with

Vilsmeier reagents, RCONR 1 R 2 /POCl 3 , afforded various alkylaminosubstitutedmethylenediphosphonates in acceptable yields, which (R ‫ב‬ H) were then reacted with aldehydes under the conditions of the Wittig-Horner reaction to furnish vinylphosphonates, and which (R ‫ב‬ H) underwent alkylation with alkyl halides to give alkylaminosubstitutedmethylenediposphonates 8. (Z)-Vinylphosphonates could be converted to (E)-isomers in refluxing ethyl acetate.

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The reaction of 2,3,4,5-tetramethylphospholylpotassium alkyl complexes [(C 4 Me 4 P) 2 LnCH(SiMe 3 ) 2 ]; these complexes were most efficiently prepared from [LnCl 3 (THF) x ], [C 4 Me 4 PK] with [LnCl 3 (THF) x ] (Ln = Nd, Sm) in a 2:1 ratio gave unsolvated ate complexes of the formula [KC 4 Me 4 P