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The synthesis and purification of 4-[14C]- and 7α[3H]-androsta-4,16-dien-3-one

✍ Scribed by M. Wilkinson; M. M. Coombs; D. B. Gower

Publisher
John Wiley and Sons
Year
1970
Tongue
French
Weight
521 KB
Volume
6
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of radioactive androsta‐4,16‐dien‐3‐one from both 4‐[^14^C]‐ and 7α‐[^3^ H]‐testosterone has been achieved using modifications of a method due to Henbest. Contrarily to this earlier report, yields of purified androstadienone were approximately 6%. Other compounds, which may be ring D isomers, have been separated by column chromatography on silicic acid impregnated with silver nitrate. Labelled 17‐epitestosterone acetate is also formed in this reaction, and may be readily isolated.

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