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The Synthesis and Preliminary Pharmacological Evaluation of a Series of Substituted 4'-Phenoxypropyl Analogues of the Atypical Antipsychotic Clozapine

✍ Scribed by Capuano, Ben; Crosby, Ian T.; McRobb, Fiona M.; Podloucka, Anna; Taylor, David A.; Vom, Amelia; Yuriev, Elizabeth


Book ID
120436742
Publisher
Commonwealth Scientific and Industrial Research Organisation Publishing
Year
2010
Tongue
English
Weight
297 KB
Volume
63
Category
Article
ISSN
0004-9425

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ChemInform Abstract: Synthesis and Pharm
✍ Y. LIAO; P. DEBOER; E. MEIER; H. WIKSTROEM πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 28 KB πŸ‘ 1 views

Synthesis and Pharmacological Evaluation of Triflate-Substituted Analogues of Clozapine: Identification of a Novel Atypical Neuroleptic. -Evaluation of triflate derivatives of clozapine and iso-clozapine shows that compound (I) is at least three times more potent than clozapine itself, indicating t