The synthesis and pharmacological evaluation of indole congeners of the calcium entry blocker verapamil
✍ Scribed by Richard M Soll; James A Parks; Thomas J Rimele; Richard J Heaslip; Alexandra Wojdan; George Oshiro; David Grimes; André Asselin
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- French
- Weight
- 672 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0223-5234
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A specific, sensitive, and accurate assay for quantitation of verapamil has been developed. The method involves a single extraction step with n-heptane, followed by evaporation at room temperature under nitrogen. 0.1 pi of the extract was injected into a capillary column coated with crosslinked 5% p
of potential metabolites a b s t r a c t Four potential metabolites of the potassium-competitive acid blocker BYK 405879 (1) were synthesized which might be formed in vivo by enzymatic oxidation of the pyran moiety or the methyl groups attached to the (hetero) aromatic system. In all cases, the oxid