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The synthesis and conformation in solution of cyclo[L-pro-L-leu-(gln)thz-(gly)thz-L-val] (dolastatin 3)

✍ Scribed by Cedric W. Holzapfel; Wynand J. van Zyl; Marita Roos

Book ID
104203304
Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
788 KB
Volume
46
Category
Article
ISSN
0040-4020

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✦ Synopsis

Ah&act: Dolastatin 3, a unique cyclic peptide, was synthesised in hi h yield. Its minimum energy conformation in solution was established by NMR spectroscopy and force ield calculations, and is character&d k by three intramolecular hydrogen bonds.

πŸ“œ SIMILAR VOLUMES

The synthesis and analysis of the confor
The synthesis and analysis of the conformation in solution of the dolastatin 3 diastereomer cyclo[-L-Pro-L-Leu-D-(Gln)Thz-(Gly)Thz-L-Val-]
✍ Bredenkamp, Martin W. ;Holzapfel, Cedric W. ;van Zyl, Wynand J. πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 525 KB

## Abstract The cyclic peptide cyclo[‐L‐Pro‐L‐Leu‐D‐(Gln)Thz‐(Gly)Thz‐L‐Val‐] (1a), which is a diastereomer of the antineoplastic agent dolastatin 3 (1b), and contains the unusual thiazole amino acids, was synthesized. All the peptide bonds of the cyclic peptide 1a are __trans__ in solution, and th