✦ LIBER ✦

Structural biochemistry. 26. Antineoplastic agents. 111. Synthesis of the modified dolastatin 3 sequence cyclo-[L-Val-L-Leu-L-Pro-(R,S)-(gln)Thz-(gly)Thz]

✍ Scribed by Pettit, George R.; Holzapfel, Cedric W.

Book ID: 127251634
Publisher: American Chemical Society
Year: 1986
Tongue: English
Weight: 531 KB
Volume: 51
Category: Article
ISSN: 0022-3263
DOI: 10.1021/jo00374a018

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Structural biochemistry. 25. Antineoplas

Structural biochemistry. 25. Antineoplastic agents. 110. Synthesis of the dolastatin 3 isomer cyclo[L-Pro-L-Leu-L-Val-(R,S)-(gln)Thz-(gly)Thz]

✍ Pettit, George R.; Holzapfel, Cedric W. 📂 Article 📅 1986 🏛 American Chemical Society 🌐 English ⚖ 730 KB

The synthesis and conformation in soluti

The synthesis and conformation in solution of cyclo[L-pro-L-leu-(gln)thz-(gly)thz-L-val] (dolastatin 3)

✍ Cedric W. Holzapfel; Wynand J. van Zyl; Marita Roos 📂 Article 📅 1990 🏛 Elsevier Science 🌐 French ⚖ 788 KB

Ah&act: Dolastatin 3, a unique cyclic peptide, was synthesised in hi h yield. Its minimum energy conformation in solution was established by NMR spectroscopy and force ield calculations, and is character&d k by three intramolecular hydrogen bonds.

The synthesis and analysis of the confor

The synthesis and analysis of the conformation in solution of the dolastatin 3 diastereomer cyclo[-L-Pro-L-Leu-D-(Gln)Thz-(Gly)Thz-L-Val-]

✍ Bredenkamp, Martin W. ;Holzapfel, Cedric W. ;van Zyl, Wynand J. 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 525 KB

## Abstract The cyclic peptide cyclo[‐L‐Pro‐L‐Leu‐D‐(Gln)Thz‐(Gly)Thz‐L‐Val‐] (1a), which is a diastereomer of the antineoplastic agent dolastatin 3 (1b), and contains the unusual thiazole amino acids, was synthesized. All the peptide bonds of the cyclic peptide 1a are __trans__ in solution, and th