The synthesis and biological activity of enediyne minor groove binding hybrids

✍ Scribed by Mark D. Wittman; John F. Kadow; David R. Langley; Dolatrai M. Vyas; William C. Rose; Wyle Solomon; Nada Zein

• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 173 KB
• Volume: 5
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/0960-894x(95)00163-n

✦ Synopsis

The potential for increasing the antitumor potency of a synthetic bicyclic enediyne by attaching a DNA recognition element has been investigated and the hybrids evaluated for antitumor activity.