The synthesis and antitumor evaluation of unsymmetrical bis-imides

✍ Scribed by Robert J. Cherney; Stephen G. Swartz; Arthur D. Patten; Emeka Akamike; Jung-Hui Sun; Robert F. Kaltenbach III; Steven P. Seitz; Carl H. Behrens; Zelleka Getahun; George L. Trainor; Mike Vavala; Mindy R. Kirshenbaum; Lisa M. Papp; Margaret P. Stafford; Philip M. Czerniak; Richard J. Diamond; Ronald J. McRipley; Roni J. Page; Janet L. Gross

• Book ID: 104364734
• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 272 KB
• Volume: 7
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/s0960-894x(96)00591-4

✦ Synopsis

Unsymmetrical bis-imides 1 were synthesized and evaluated as potential antitumor agents. These novel bis-imides were assessed using three criteria: in vitro cytotoxicity (L1210), in vitro DNA binding, and in vivo studies with human tumor xenografts in mice. These studies identified DMP 315 as a potent, water soluble antitumor agent.