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Synthesis of bis(imides) and bis(half amides) of NN?-ethylenebis(iminodiacetic acid)

✍ Scribed by Houghton, Roy P.; Williams, Emyr


Book ID
120653212
Publisher
Royal Society of Chemistry
Year
1982
Weight
469 KB
Volume
0
Category
Article
ISSN
1472-7781

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The synthesis and antitumor evaluation o
✍ Robert J. Cherney; Stephen G. Swartz; Arthur D. Patten; Emeka Akamike; Jung-Hui πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 English βš– 272 KB

Unsymmetrical bis-imides 1 were synthesized and evaluated as potential antitumor agents. These novel bis-imides were assessed using three criteria: in vitro cytotoxicity (L1210), in vitro DNA binding, and in vivo studies with human tumor xenografts in mice. These studies identified DMP 315 as a pote