## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
The Syntheses of Tricyclic Analogues of O6-Methylguanine.
β Scribed by David M. Hammond; Dolores Edmont; Ana R. Hornillo-Araujo; David M. Williams
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 92 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
For Abstract see ChemInform Abstract in Full Text.
π SIMILAR VOLUMES
Activity of 06-methylguanine-DNA methyltransferase (MGMT) is well related with drug resistance of tumor cells to chloroethylnitrosoureas (CENUs), because MGMT removes CENU-induced O6-alkyIguanines in DNA by accepting the alkyl group at a cysteine moiety. Inactivation of MGMT is a feasible way to ove
The DNA-repair protein O 6 -methylguanine-DNA methyltransferase (MGMT) is a decisive determinant of resistance of tumor cells to methylating and chloroethylating anti-cancer drugs. Therefore, selective inhibition of MGMT in tumors is expected to cause tumor sensitization. Several inhibitors of MGMT
Mutagen-induced chromatid aberrations are not DNA as well as in FokI sequences of the field bean randomly distributed along the metaphase chromo-after exposure to MNU. In either case, similar numsomes. In the field bean (Vicia faba), defined late-bers of adducts per nucleotide were found immedirepli