The symmetry of radiation-induced chromatid exchanges in relation to the cell cycle in Chinese hamster cells in vivo and in vitro
โ Scribed by P.P.W. van Buul; R. Ricordy; F. Spirito; A.D. Tates
- Book ID
- 113191283
- Publisher
- Elsevier Science
- Year
- 1978
- Tongue
- English
- Weight
- 324 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0027-5107
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## Abstract The level of sister chromatid exchanges, both spontaneous and induced by UV light or ethylmethanesulphonate (EMS), in Chinese hamster V79/AP4 cell line, is partially reduced upon cocultivation with human cells. Normal and xeroderma pigmentosum (XP) cells are equally effective. On the ba
Culture of cells in high exogenous levels (greater than 10(-4) M) of bromodeoxyuridine (BrdUrd) or thymidine will increase the baseline sister chromatid exchange (SCE) frequency. The effect is thought to be related to the balance of the DNA precursors thymidine and deoxycytidine. Exogenous addition