The Suzuki-Miyaura cross coupling reactions on solid support. Link to solution phase directed ortho metalation. The Leznoff acetal linker approach to biaryl and heterobiaryl aldehydes

✍ Scribed by S. Chamoin; S. Houldsworth; C.G. Kruse; W. Iwema Bakker; V. Snieckus

• Book ID: 104259341
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 169 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)00779-5

✦ Synopsis

The synthesis of the titled compounds by Suzuki-Miyaura cross coupling on Merrifield resin -Leznoff acetal -linked halo benzaldehydes followed by mild acid hydrolysis is reported; synthetic utility for heterocycles based on solution phase Directed ortho Metalation chemistry is demonstrated.