The Stille cross coupling reactions on solid support. Link to solution phase directed ortho metalation. An ester linker approach to styryl, biaryl and heterobiaryl car☐ylic acids

The Suzuki-Miyaura cross coupling reacti

The Suzuki-Miyaura cross coupling reactions on solid support. Link to solution phase directed ortho metalation. The Leznoff acetal linker approach to biaryl and heterobiaryl aldehydes

✍ S. Chamoin; S. Houldsworth; C.G. Kruse; W. Iwema Bakker; V. Snieckus 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 169 KB

The synthesis of the titled compounds by Suzuki-Miyaura cross coupling on Merrifield resin -Leznoff acetal -linked halo benzaldehydes followed by mild acid hydrolysis is reported; synthetic utility for heterocycles based on solution phase Directed ortho Metalation chemistry is demonstrated.