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The sulfur-cyanolysis sites of serum albumin: Metabolite competition studies

โœ Scribed by Jarabak, Rebecca ;Westley, John

Book ID
102875586
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
699 KB
Volume
4
Category
Article
ISSN
0887-2082

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โœฆ Synopsis

In the presence of a source of sulfane sulfur, a cyanolysis reaction catalyzed by serum albumin may contribute to cyanide detoxication. The active site for this catalysis by serum albumin has been investigated in competition studies with ligands that have known albumin binding sites. Despite complications caused by the occurrence of multipIe primary and secondary sites for many ligands, the results show that the primary sites for bilirubin, steroids, indoles, aspirin, and palmitate are distinct from that for sulfur. Laurate is a tight-binding partial inhibitor of the cyanolysis reaction, competitive with cyanide rather than with sulfur. In view of the formal mechanism previously established for the catalyzed reaction, this result indicates that the sulfur-cyanolysis site is probably near the site occupied by laurate.

๐Ÿ“œ SIMILAR VOLUMES

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