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Localization of the sulfur-cyanolysis site of serum albumin to subdomain 3-ab

✍ Scribed by Jarabak, Rebecca ;Westley, John

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
469 KB
Volume
6
Category
Article
ISSN
0887-2082

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✦ Synopsis

The results of kinetic experiments measuring the effects of a variety of ligands on the sulfur-cyanolysis reaction catalyzed by serum albumin point to the conclusion that the active site for cyanolysis is on subdomain 3-AB. Relationships among the inhibition by short-chain fatty acids, the activation by p-nitrophenyl acetate, and the influence of bilirubin and L-tryptophan on these effects indicate that the cyanolysis active site and the known primary binding site for indoles are both near, but on opposite sides of, tyrosine-409 of bovine albumin (tyrosine-411 of human albumin).

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