The study of the lipophilicity of some aminoalkanol derivatives with anticonvulsant activity
✍ Scribed by Anna Waszkielewicz; Natalia Szkaradek; Elżbieta Pękala; Fabiola Galzarano; Henryk Marona
- Book ID
- 102772479
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 614 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0269-3879
- DOI
- 10.1002/bmc.1453
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## Abstract The lipophilicity of a number of __N__‐acyl derivatives of __trans__‐ or __cis__‐: racemic, (1__R__,2__R__)‐ or (1__S__,2__S__)‐aminocyclohexanol (1–13) exhibiting anticonvulsant activity was investigated. Their lipophilicity (__R__~m0~) was determined using reversed‐phase thin‐layer ch
Two closely related N-substituted valpromide derivatives: N-valproyl glycinamide and N-valproyl glycine are comparatively analyzed, the first of which is antiepileptic active whereas the second is not. The study is based on a conformational analysis using an AM1 Hamiltonian that not only search for