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The Structures of the Frenatin Peptides from the Skin Secretion of the Giant Tree Frog Litoria Infrafrenata

✍ Scribed by M. J. Raftery; R. J. Waugh; J. H. Bowie; J. C. Wallace; M. J. Tyler

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
583 KB
Volume
2
Category
Article
ISSN
1075-2617

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✦ Synopsis

Abstract

The granular dorsal glands of the giant tree frog Litoria infrafrenata contain five peptides including caerulein (a known neuropeptide), and four new peptides named frenatins 1 (MH^+^ = 1140 Da), 2 (1423), 3 (2180) and 4 (2493). The amino acid sequences of the frenatins are detailed: their structures do not correspond to those of peptides isolated from other amphibians or animals. Frenatin 3, Gly‐Leu‐Met‐Ser‐Val‐Leu‐Gly‐His‐Ala‐Val‐Gly‐Asn‐Val‐Leu‐Gly‐ Gly‐Leu‐Phe‐Lys‐Pro‐Lys‐Ser‐(OH), has wide spectrum antimicrobial properties.

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