The structures of macbecin I and II, new antitumor antibiotics
β Scribed by Masayuki Muroi; Konomi Haibara; Mitsuko Asai; Toyokazu Kishi
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- French
- Weight
- 230 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0040-4039
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The isolation and structure elucidation of rebeccamycin l\_, a new antitumor agent from Nocardia aerocoligenes, is described. The NMR spectra of 1 and its peracetate 2 are discussed. Recently we have isolated a novel antitumor antibiotic rebeccamycin 1 from fermentations of Nocardia aerocoligenes, s
The antitumor antibiotic 'rubiflavin' was investigated. It was shown to be a mixture of several compounds, nine of which -after isolation by HPLC -could be identified by 'H-NMR spectroscopy. The rubiflavins A (4), B (S), C-l(6), C-2 (7), D (8), and E (9) are pluramycin antibiotics differing only in
Krivoruchko. -Chem. Abst. 1\_1. 50409 (1969). 9) The C-H long range couplings observed between C-4a (681.6) and 6-H (66.89) and between C-3 (675.3) and 3-CH3 (61.24) indicates that the remaining quaternary oxycarbon (680.2) is assignable to C-12b.