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The Structure of the Amyloid-β Peptide High-Affinity Copper II Binding Site in Alzheimer Disease

✍ Scribed by Streltsov, Victor A.; Titmuss, Stephen J.; Epa, V. Chandana; Barnham, Kevin J.; Masters, Colin L.; Varghese, Joseph N.

Book ID: 119922019
Publisher: Biophysical Society
Year: 2008
Tongue: English
Weight: 475 KB
Volume: 95
Category: Article
ISSN: 0006-3495
DOI: 10.1529/biophysj.108.134429

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## Abstract Amyloid‐β peptide (Aβ) is the principal constituent of plaques associated with Alzheimer's disease (AD) and is thought to be responsible for the neurotoxicity associated with the disease. Copper binding to Aβ has been hypothesized to play an important role in the neruotoxicity of Aβ and