The structure of aureolic acid (mithramycin)
β Scribed by G.P. Bakhaeva; Yu.A. Berlin; E.F. Boldyreva; O.A. Chuprunova; M.N. Kolosov; V.S. Soifer; T.E. Vasiljeva; I.V. Yartseva
- Book ID
- 104215347
- Publisher
- Elsevier Science
- Year
- 1968
- Tongue
- French
- Weight
- 179 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
β¦ Synopsis
AUEEOIZO acid from Stre&oweee ep. (I), the pareat substanoe ef an import-asIs group of entittmour entm.otiosr had reoently been &own (2) to beAden-tin&l with antibiotics U-7017 (3) and titb=mycin (4). We hare now found it to poeaose 6t-s I. I The antibiotic; is a glycoside Ch024 Cm-p. 180-183', from Me$JO; lal;o -5l"r o 0.4 in EtOH) that on acid bydrolysle yielded ohromowAnone (v), XLlsycaroee (II), D-03.iroee (III) and II-oliose (Iv) in the ratio 1:1:3:1,
π SIMILAR VOLUMES
The Structures of Premithramycinone and Demethylpremithramycinone, Plausible Early Intermediates of the Aureolic Acid Group Antibiotic Mithramycin. -The structures of title compounds (I), determined in particular by one-and two-dimensional NMR spectroscopy, suggest that aureolic acid antibiotics ar
Biosynthetic studies on mithramycin (1, aureolic acid) using to a great extent modern genetic methods revealed several novel aspects of the biosynthesis of this class of antitumor agent. It could be proven that the aglycon moiety of the aureolic acids is constructed by a type II polyketide synthase