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The structure determination of panellon and panellol, two 14-noreudesmanes isolated from resupinatus leightonii

✍ Scribed by Anders Sundin; Heidrun Anke; Karl-Erik Bergquist; Anke Mayer; William S. Sheldrick; Marc Stadler; Olov Sterner

Book ID: 104204415
Publisher: Elsevier Science
Year: 1993
Tongue: French
Weight: 370 KB
Volume: 49
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(01)87227-6

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✦ Synopsis

The structures of two fungal norsesquiterpenes containing a diepoxide functionality, isolated from cultures of the basidiomycete Resupinatus leightonii, were elucidated by a combination of X-ray analysis, NMR spectroscopy and molecular mechanics calculations.

The noreudesmane panellon (1) was recently isolated as the active principle from the culture filtrate of the basidiomycete Resupinatus leightonii. 1 It exhibits strong antimicrobial, cytotoxic and phytotoxic activities, while the reduced derivative panel101 (2) isolated from the same fungus was practically devoid of biological activities. l

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