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The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase

โœ Scribed by Loll, Patrick J.; Picot, Daniel; Garavito, R. Michael

Book ID
109965037
Publisher
Nature Publishing Group
Year
1995
Tongue
English
Weight
961 KB
Volume
2
Category
Article
ISSN
1072-8368

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Crystal structures of thymidylate syntha
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โœ Rogerio R. Sotelo-Mundo; Liming Changchien; Frank Maley; William R. Montfort ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 142 KB

Thymidylate synthase (TS) catalyzes the folate-dependent methylation of deoxyuridine monophosphate (dUMP) to form thymidine monophosphate (dTMP). We have investigated the role of invariant arginine 166, one of four arginines that contact the dUMP phosphate, using site-directed mutagenesis, X-ray cry