Crystal structures of thymidylate syntha
โ
Rogerio R. Sotelo-Mundo; Liming Changchien; Frank Maley; William R. Montfort
๐
Article
๐
2006
๐
John Wiley and Sons
๐
English
โ 142 KB
Thymidylate synthase (TS) catalyzes the folate-dependent methylation of deoxyuridine monophosphate (dUMP) to form thymidine monophosphate (dTMP). We have investigated the role of invariant arginine 166, one of four arginines that contact the dUMP phosphate, using site-directed mutagenesis, X-ray cry