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The stimulus-secretion coupling of amino acid-induced insulin release synergistic effects of L-glutamine and 2-keto acids upon insulin secretion☆

✍ Scribed by SENER, A; HUTTON, J; MALAISSE, W

Book ID
123100755
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
492 KB
Volume
677
Category
Article
ISSN
0304-4165

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The stimulus-secretion coupling of amino
The stimulus-secretion coupling of amino acid-induced insulin release
✍ Michael Welsh; Abdullah Sener; Francine Malaisse-Lagae; Willy J. Malaisse 📂 Article 📅 1984 🏛 Springer 🌐 English ⚖ 345 KB

Aminooxyacetate, an inhibitor of cytosolic transamination reactions, inhibited insulin release evoked by either 2-ketoisocaproate or L-leucine in rat pancreatic islets incubated in the presence of L-glutamine or L-asparagine. As a rule, aminooxyacetate also inhibited the oxidation of these nutrient