The stimulation of tumor cell growth by a substance produced by normal and tumor cells
โ Scribed by Yasuo Ichikawa; Michael Paran; Leo Sachs
- Publisher
- John Wiley and Sons
- Year
- 1969
- Tongue
- English
- Weight
- 408 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0021-9541
No coin nor oath required. For personal study only.
โฆ Synopsis
It has been shown that a dialyzable substance produced by normal and tumor cells can stimulate the growth of a myeloid, erythroid, and two lymphoid leukemias, and a sarcoma. The growth stimulation of the tumor cells was observed as an increase in cloning efficiency and number of cells per colony. Rat granulocytes stimulated the growth of mouse tumor cells as efficiently as a variety of mouse cells, The stimulating substance was found in conditioned medium, and it was produced by all the normal and tumor cells tested.
๐ SIMILAR VOLUMES
Facilitated tumor growth was observed in syngeneic animals after the subcutaneous inoculation of these animals with normal syngeneic spleen cells a n d tumor cells previously mixed in vitro. T u m o r incidence, latency, a n d growth rate appear quantitatively directly related to the ratio of spleen
Bone is one of the most common sites of metastasis in melanoma and breast cancer cells. Human melanoma (A375M) and human breast cancer (MDA-MB-231) cells form osteolytic bone metastasis in vivo when these tumor cells are injected into the left ventricles of BALB/c nude mice. These tumor cells promot
Dendritic cells (DCs) are "professional" antigen-presenting cells capable of stimulating T-cell proliferation and cytotoxicity when loaded with and presenting specific antigens, including tumor antigens. We demonstrated the stimulation of an autologous cytotoxic T-cell response elicited by DC loaded