๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

The stereoselective metabolism of halofantrine to desbutylhalofantrine in the rat: Evidence of tissue-specific enantioselectivity in microsomal metabolism

โœ Scribed by Negar Gharavi; Somayeh Sattari; Anooshirvan Shayeganpour; Ayman O.S. El-Kadi; Dion R. Brocks

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
637 KB
Volume
19
Category
Article
ISSN
0899-0042

No coin nor oath required. For personal study only.

๐Ÿ“œ SIMILAR VOLUMES

The effect of experimental hyperlipidemi
The effect of experimental hyperlipidemia on the stereoselective tissue distribution, lipoprotein association and microsomal metabolism of (ยฑ)-halofantrine
โœ Jigar P. Patel; Jackie G. Fleischer; Kishor M. Wasan; Dion R. Brocks ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 178 KB ๐Ÿ‘ 1 views

The effect of hyperlipidemia on the biodistribution of (+/-)-halofantrine (HF) was studied in rats. Plasma, adipose, and highly perfused tissues heart, lung, liver, kidney, spleen and brain were harvested for up to 48 h after dosing animals with 2 mg/kg (+/-)-HF intravenously by tail vein. Stereospe

Stereoselective pharmacokinetics of desb
Stereoselective pharmacokinetics of desbutylhalofantrine, a metabolite of halofantrine, in the rat after administration of the racemic metabolite or parent drug
โœ Dion R. Brocks ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 114 KB ๐Ÿ‘ 1 views

## Abstract The main objective of this study was to determine the pharmacokinetics of the enantiomers of desbutylhalofantrine (DHF), a metabolite of halofantrine (HF), in the rat. Rats received either intravenous (2 mg/kg) or oral (7 mg/kg) (ยฑ)โ€DHF HCl, or (ยฑ)โ€HF HCl intravenously (3 mg/kg). Enanti

The effects of variation in dietary prot
The effects of variation in dietary protein and ethanol on hepatic microsomal drug metabolism in the rat
โœ Mack C. Mitchell; Esteban Mezey; Willis C. Maddrey ๐Ÿ“‚ Article ๐Ÿ“… 1981 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 484 KB ๐Ÿ‘ 1 views

The effects of chronic ethanol consumption and variations in dietary protein content on micro-soma1 drug metabolism were studied in rats pair-fed liquid diets containing 10, 20, or 30% dietary protein with or without ethanol. In uiuo drug metabolism was measured by aminopyrine breath tests and amino