CUCDRRITACINS Bse the various the Cucurbitaceae. Some have activity.4 Based on dehydrogenation bitter highly toxic principles oocurring in been investigated for their anti-tumor experiments and on the nature of the side chain, a regular tetracyclio triterpenoid carbon skeleton has been assigned to t
The stereochemistry of the cucurbitacins
โ Scribed by David Lavie; Youval Shvo; Otto Richard Gottlieb
- Publisher
- Elsevier Science
- Year
- 1960
- Tongue
- French
- Weight
- 341 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
THE stereochemistry of ring A of some of the cucurbitacins has been discussed in a previous communication. 4 We wish to report now the experiments which led us to present most of the stereochemistry of the four naturally occurring cucurbitacins: elatericin A (Ia), cucurbitacin B (Ib), elatericin B (IIa) and elaterin (IIb), leaving only the configuration of C-9 undetert .A !Q u , d r f a R=H, R'=H r'-) R=H, R'=Ac \I 'Y c R=Ac,R'=H d R=Ac,R'=Ac
๐ SIMILAR VOLUMES
THE cucurbitacins are M interesting group of bitter the Cucurbitaceae.' A constitution (I) was recently cucurbitacin E. The related cucurbitacin B R = side chain). Cucurbitacins B, D, E and may be represented as in (II, I have all been correlated U.K. 13, Pennsylvania principles found in proposed\*
University, TWO orystalline oompounds have been isolated from Eohinocyctie fabacea, cuourbitacin B and fabacein. Cucurbitacin B appears to have the molecular formula c3p4608 , and structural formula I recently has been proposed for lt.2 Fabaoein originally was assigned the molecular formula C HO
Cucurbitacin B, a natural triterpenoid is well-known for its strong anticancer activity, and recent studies showed that the compound inhibits JAK/STAT3 pathway. In this study, we demonstrate for the first time that cucurbitacin B is also a potent inhibitor of NF-kB activation. Our results showed tha