THE cucurbitacins are M interesting group of bitter the Cucurbitaceae.' A constitution (I) was recently cucurbitacin E. The related cucurbitacin B R = side chain). Cucurbitacins B, D, E and may be represented as in (II, I have all been correlated U.K. 13, Pennsylvania principles found in proposed\*
Constitution of the Cucurbitacins
β Scribed by David Lavie; Youval Shvo; Otto Richard Gottlieb; Erwin Glotter
- Publisher
- Elsevier Science
- Year
- 1961
- Tongue
- French
- Weight
- 425 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
CUCDRRITACINS Bse the various the Cucurbitaceae. Some have activity.4 Based on dehydrogenation bitter highly toxic principles oocurring in been investigated for their anti-tumor experiments and on the nature of the side chain, a regular tetracyclio triterpenoid carbon skeleton has been assigned to them, and structures Ia and Ib have been proposed for elatericin B and elatesin respectively. We now wish to report our experimental results leading to the modification of their structures to IIa and IIb. By previous 1
π SIMILAR VOLUMES
THE stereochemistry of ring A of some of the cucurbitacins has been discussed in a previous communication. 4 We wish to report now the experiments which led us to present most of the stereochemistry of the four naturally occurring cucurbitacins: elatericin A (Ia), cucurbitacin B (Ib), elatericin B (