The stabilizing effect of spermine and related polyamines and bacterial protoplasts
โ Scribed by J. Mager
- Book ID
- 115788192
- Publisher
- Elsevier Science
- Year
- 1959
- Weight
- 205 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0006-3002
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Polyamine amides are useful in gene delivery as synthetic (non-viral) vectors or mimics of polycationic histones. The application of a homologation strategy, based upon reductive alkylation, allows unsymmetrical polyamine amides to be prepared in good yield. The interaction of this polyamine amide w
## Homologation of Polyamines in the Synthesis of Lipo-Spermine Conjugates and Related Lipoplexes. -In continuation of efforts on the synthesis of polyamine amides useful in gene delivery as synthetic vectors or mimics of polycationic histones, the amides ( IV) and (VIII) are prepared. The synthe