Protein microencapsulation in biodegradable polymers is a promising route to provide for sustained release. One important characteristic in this regard is the size of the particles encapsulated within the microspheres. In this investigation, we have employed spray-freeze drying to generate particles
The Stabilization and Encapsulation of Human Growth Hormone into Biodegradable Microspheres
β Scribed by OluFunmi L. Johnson; Warren Jaworowicz; Jeffrey L. Cleland; Leonie Bailey; Margarita Charnis; Eileen Duenas; Chichih Wu; Douglas Shepard; Sheila Magil; Thomas Last; Andrew J. S. Jones; Scott D. Putney
- Book ID
- 110309202
- Publisher
- Springer US
- Year
- 1997
- Tongue
- English
- Weight
- 639 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0724-8741
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The development of a stable sustained-release formulation of recombinant human nerve growth factor (rhNGF) for the treatment of neuronal diseases is described. The protein was encapsulated into poly(lactic-co-glycolic) acid (PLGA) microspheres using a spray freeze drying technique. Liquid nitrogen a
Recombinant human growth hormone (rhGH) was encapsulated within poly(D,L-lactic-co-glycolic acid) microspheres by a double emulsion solvent evaporation method. A mixture of methylene chloride and ethyl acetate in varying volume ratios was used for the microsphere preparation. Protein release profile