Effect of excipients on the encapsulation efficiency and release of human growth hormone from dextran microspheres
โ Scribed by K.D.F. Vlugt-Wensink; Y.J. Meijer; M.J. van Steenbergen; R. Verrijk; W. Jiskoot; D.J.A. Crommelin; W.E. Hennink
- Book ID
- 116437755
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- French
- Weight
- 355 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0939-6411
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Protein microencapsulation in biodegradable polymers is a promising route to provide for sustained release. One important characteristic in this regard is the size of the particles encapsulated within the microspheres. In this investigation, we have employed spray-freeze drying to generate particles
We have investigated the effect of mannitol, sorbitol, methyl R-D-mannopyranoside, lactose, trehalose, and cellobiose on the stability and structure of the pharmaceutical protein recombinant human growth hormone (rhGH) in the lyophilized state. All excipients afforded significant protection of the p