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The stability of 6-hydroxydopamine under minipump conditions

✍ Scribed by D. A. Haycock; M. F. Bear

Publisher: Springer-Verlag
Year: 1984
Tongue: English
Weight: 340 KB
Volume: 56
Category: Article
ISSN: 0014-4819
DOI: 10.1007/bf00237455

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✦ Synopsis

A number of investigators have recently used osmotic minipumps to continuously deliver the neurotoxin 6-hydroxydopamine (6-OHDA) to kitten cerebral cortex for periods up to 7 days. Because this compound is known to be particularly labile, we studied the stability of 6-OHDA stored under conditions similar to those found in an osmotic minipump. In 0.4% ascorbic acid, 4 mM 6-OHDA-HBr was found to be stable for at least one week as determined by (1) assay of the drug by high performance liquid chromatography and electrochemical detection and (2) test of the drug's ability to deplete mouse heart norepinephrine.

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