In order to more easily study the absorption, excretion, and distribution patterns of 7-chloro-1 -(cyclopropylmethyl)-5-phenyl-1 H-1,4-benzodiazepin-
The stability of 1-cyclopropylmethyl-5(o-fluorophenyl)-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one (KB-509) in aqueous solution
✍ Scribed by Koichi, A
- Book ID
- 123115381
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- English
- Weight
- 448 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0378-5173
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## Abstract Two benzodiazepines, Diazepam and Flunitrazepam, labeled with carbon‐14 in position 5 of the diazepine ring have been synthesized. Use of a condensation between iminochlorides and ^14^C‐benzonitriles, followed by exhaustive methylation of the resulting quinazolines and hydrolyses is des
## Abstract 7‐Chloro‐1,3‐dihydro‐5‐(2‐fluorophenyl)‐1‐methyl‐2H‐1,4‐benzodiazepin‐2‐one (Fludiazepam) (I), an anti‐anxiety agent, was labelled with carbon‐14 at C‐5 position for metabolic studies. The reaction sequence for the synthesis is shown in Fig. 2. o‐Fluorobenzoic‐^14^C acid (IV) was prepar