The split-hand and split-foot anomaly in a central African Negro population
β Scribed by Viljoen, D. L. ;Beighton, P.
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 468 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0148-7299
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## Abstract **BACKGROUND:** Split hand foot malformation (SHFM) (cleft hand, central ray deficiency) is a highly variable malformation that shows genetic heterogeneity with at least five loci mapped to date. SHFM occurs as an isolated finding or in association with other anomalies, including congen
## Abstract **BACKGROUND:** At least five distinct loci have been implicated in split hand foot malformation (SHFM). Establishing genotype/phenotype correlations at the chromosomal level may elucidate responsible developmental genes and improve patient management. In our analysis of previously publ