Genotype–phenotype correlations in mapped split hand foot malformation (SHFM) patients
✍ Scribed by Alison M. Elliott; Jane A. Evans
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 161 KB
- Volume
- 140A
- Category
- Article
- ISSN
- 1552-4825
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## Abstract **BACKGROUND:** At least five distinct loci have been implicated in split hand foot malformation (SHFM). Establishing genotype/phenotype correlations at the chromosomal level may elucidate responsible developmental genes and improve patient management. In our analysis of previously publ
## Abstract Split‐hand/foot malformation (SHFM), or ectrodactyly, is characterized by underdeveloped or absent central digital rays, clefts of the hands and feet, and variable syndactyly of the remaining digits. SHFM occurs as both an isolated finding and a component of many syndromes. SHFM is a he