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The spinal anaesthetic effect of dextromethorphan, dextrorphan, and 3-methoxymorphinan

✍ Scribed by Yu-Wen Chen; Yen-Chia Chen; Ching-Nan Lin; Chin-Chen Chu; Mao-Tsun Lin; Jhi-Joung Wang; Cheng-Hsing Kao

Book ID
113586966
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
316 KB
Volume
569
Category
Article
ISSN
0014-2999

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## Abstract Dextromethorphan is used as a probe drug for assessing CYP2D6 and CYP3A4 activity __in vivo__ and __in vitro__. A SIM GC/MS method without derivatization for the simultaneous determination of dextromethorphan and its metabolites, dextrorphan, 3‐methoxymorphinan and 3‐hydroxymorphinan, i