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The specificity of inhibition of debrisoquine 4-hydroxylase activity by quinidine and quinine in the rat is the inverse of that in man

โœ Scribed by Shinichi Kobayashi; Stephen Murray; David Watson; Dorothea Sesardic; Donald S. Davies; Alan R. Boobis

Book ID
115781081
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
611 KB
Volume
38
Category
Article
ISSN
0006-2952

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Is the activation of aflatoxin B1catalys
Is the activation of aflatoxin B1catalysed by the same form of cytochrome P-450 as that 4-hydroxylating debrisoquine in rat and/or man?
โœ Simon Plummer; Alan R. Boobis; Donald S. Davies ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› Springer-Verlag ๐ŸŒ English โš– 559 KB

A possible association between the metabolic activation of aflatoxin B1 (AFB1) to a mutagen and the 4-hydroxylation of debrisoquine, which shows genetic variation both in man and in the rat, was investigated. Hepatic microsomal fractions from female DA and Fischer rats catalyse, at the same rate, th