The specific blocking of humoral immune cytolysis mediated by anti-tumor antibodies degraded by lysosomal enzymes of tumor origin

Specific anti-tumor responses by culture

Specific anti-tumor responses by cultured immune spleen cells. I. In vitro culture method and initial characterization of factors which block immune cell-mediated cytotoxicity in vitro

✍ Karen Nelson; Sylvia B. Pollack; Karl Erik Hellström 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 French ⚖ 642 KB

## Abstract Spleen cells from BALB/c mice which either bore syngeneic sarcomas or were normal controls were cultured __in vitro__. The culture supernatants of spleen cells from tumor‐bearing mice inhibited (blocked) specific cell‐mediated cytotoxicity to the tumor borne by the spleen donor. They al