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The solid phase synthesis of unsymmetrical phosphinic acids

✍ Scribed by Philip B Cox; Vincent M Loh Jr.; Claude Monteils; Anthony D Baxter; E.Andrew Boyd

Book ID: 104211441
Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 110 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)01897-9

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✦ Synopsis

This letter describes a method for the synthesis of unsymmetrical phosphinic acids by the phosphinylation of a resin-bound aldehyde and subsequent 'P' alkylation. This synthetic transformation is very difficult to perform as selectively in solution and therefore further exemplifies the powerful nature of solid phase organic chemistry (SPOC).

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