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The solid phase synthesis of peptides containing an arginine residue with an unprotected guanidine group

✍ Scribed by Yu. A. Rubina; Zh. D. Bespalova; V. N. Bushuev


Book ID
110669433
Publisher
SP MAIK Nauka/Interperiodica
Year
2000
Tongue
English
Weight
852 KB
Volume
26
Category
Article
ISSN
1068-1620

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πŸ“œ SIMILAR VOLUMES


Direct incorporation of unprotected keto
✍ Lisa A. Marcaurelle; Carolyn R. Bertozzi πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 245 KB

An amino acid bearing an unprotected ketone group, (2S)-aminolevulinic acid, was incorporated into a synthetic peptide using standard FroΒ©c-based solid-phase methods. The ketone group remained unharmed during the synthesis and provided a uniquely reactive functional group for covalent modification o

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Et a ) L-Amino-acid ester, cat. TsOH, MeCN, 30-80". b ) HgCI,, MeCN/H,O 3:1, r.t. Pd(dba), (3 mol-Yo) and PPh, (12 mol-%) at 25-30Β° for 8-10 h gave the mono-ally1 derivatives 4a-e, 5a, b, and 6a, b in yields of 40-80%0 (Scheme 3 ) , the diastereoisomeric excess (de) being 1 H 5 %, as reported earlie

Use of an allylic anchor group and of it
✍ F. GuibΓ©; O. Dangles; G. Balavoine; A. Loffet πŸ“‚ Article πŸ“… 1989 πŸ› Elsevier Science 🌐 French βš– 209 KB

protected The allylic handle -0-CH2-CH-CH-CH2-0-CH2-CO-has been used in the synthesis of peptide fro ments on aminomethyl polystyrene. The palladium-catalyzed hydrostannolytic cleavage il of t e peptide fragments from the resin occurs under very mild conditions.