A novel ring expansion of the pleuromuti
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Dane M Springer; Jason T Goodrich; Stella Huang
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Article
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2002
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Elsevier Science
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French
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An unprecedented cyclooctane to cyclononene ring expansion in the pleuromutilin skeleton, affording two main products, has been discovered. The process entails an intramolecular cyclization of an olefin onto an oxonium ion, followed by 1,2 migration of a carbon of the cyclooctane ring.