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A novel ring expansion of the pleuromutilin skeleton

✍ Scribed by Dane M Springer; Jason T Goodrich; Stella Huang

Book ID: 104251320
Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 98 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00902-4

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✦ Synopsis

An unprecedented cyclooctane to cyclononene ring expansion in the pleuromutilin skeleton, affording two main products, has been discovered. The process entails an intramolecular cyclization of an olefin onto an oxonium ion, followed by 1,2 migration of a carbon of the cyclooctane ring.

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