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The Sites of Action Of Azapurines in Tetrahymena

✍ Scribed by Virginia C. Dewey; G. W. Kidder

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 765 KB
Volume: 1
Category: Article
ISSN: 0233-111X
DOI: 10.1002/jobm.19600010102

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✦ Synopsis

In 1949 the suggestion was made that the guanine analog, 8-azaguanine, exerted an intense inhibition of the growth of Tetrahymena pyriformis by reason of its incorporation into the nucleic acids of the ciliate KIDDER, DEWEY, PARKS and WOODSIDE 1949). Support for this hypothesis was offered by the report (MITCHELL, SKIPPER and BENNETT 1950) that labeled azaguanine is found in the nucleic acids of both normal and tumor tissues of mice. In 1952 HEINRICH, DEWEY, PARKS and KIDDER reported

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