Acetylation of internal lysine residues of core histone N-terminal domains has been found correlatively associated with transcriptional activation in eukaryotes for more than three decades. Recent discoveries showing that several transcriptional regulators possess intrinsic histone acetyltransferase
The sirtuin class of histone deacetylases: Regulation and roles in lipid metabolism
โ Scribed by Fiorino, Erika; Giudici, Marco; Ferrari, Alessandra; Mitro, Nico; Caruso, Donatella; De Fabiani, Emma; Crestani, Maurizio
- Book ID
- 121868853
- Publisher
- John Wiley and Sons
- Year
- 2014
- Tongue
- English
- Weight
- 803 KB
- Volume
- 66
- Category
- Article
- ISSN
- 1521-6543
- DOI
- 10.1002/iub.1246
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The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunctions, heart disease, cancer, memory impairment, aging, and metabolic disorders.
The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunctions, heart disease, cancer, memory impairment, aging, and metabolic disorders.