## Abstract A key feature in the malignant behavior of glioblastoma is the tendency to invade host brain tissue surrounding the primary tumor site. Several members of the matrix metalloproteinase family are thought to contribute to this invasive capacity. A single nucleotide polymorphism has been d
The single nucleotide polymorphisms of matrix metalloproteinase-1 in patients with systemic sclerosis
β Scribed by Chung-II Joung; Young-In Na; Eun-Soon Shin; Yoon-Kyoung Sung; Dae-Hyun Yoo; Jae-Bum Jun
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 184 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0172-8172
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## Abstract Matrix metalloproteinase (MMP)β1 is associated with tumor cell invasion and metastasis, and its promoter polymorphism has been shown to influence the transcriptional level. Our study explored the association between this polymorphism and renal cell carcinoma in a Japanese population. DN
## Abstract ## Objective Giant cell arteritis (GCA) is the most common type of primary vasculitis. Matrix metalloproteinase 9 (MMPβ9) is present in arterial lesions of GCA and may be involved in its pathogenesis. We investigated whether certain genotypes of 4 singleβnucleotide polymorphisms (SNPs)
## Abstract ## Objective Geneβgene interaction, or epistasis, is considered a ubiquitous component of complex human diseases such as systemic sclerosis (SSc). Epistasis is difficult to model by traditional parametric approaches; therefore, nonparametric computational algorithms, such as multifacto