## Abstract ## Objective To examine the clinical correlates of thrombocytopenia and the value of thrombocytopenia as a predictor of disease activity, damage accrual, and mortality in patients with systemic lupus erythematosus (SLE). ## Methods SLE patients participating in a longitudinal multiet
The significance of thrombocytopenia in systemic lupus erythematosus
β Scribed by Marian H. Miller; Dr Murray B. Urowitz; Dafna D. Gladman
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 534 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Seven patients with thrombocytopenia and systemic lupus erythematosus were treated with intravenous (IV) doses of human immunoglobulin to assess clinical response and to examine the mechanism of action of IV immunoglobulin in these patients. Five of 7 patients had a >50% increase in their platelet c
Sera from patients with SLE frequently contain IgM and IgG antibodies with multiple specificities for lymphocyte surface determinants, including autologous antigens. The IgM antibodies are of relatively low binding avidity and exhibit broad reactivity with B and T lymphocytes from most individuals.
## Abstract In a prospective study of 226 patients with systemic lupus erythematosus (SLE), 91 patients (40%) had Raynaud's phenomenon. These patients were compared to 135 patients without Raynaud's phenomenon. Patients with Raynaud's phenomenon had a greater incidence of arthritis (__P__ < 0.02),