Significance of antibody to DNA in systemic lupus erythematosus
β Scribed by Salvador P. Casals; George J. Friou; Lynn L. Myers
- Publisher
- John Wiley and Sons
- Year
- 1964
- Tongue
- English
- Weight
- 740 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Sera from patients with SLE frequently contain IgM and IgG antibodies with multiple specificities for lymphocyte surface determinants, including autologous antigens. The IgM antibodies are of relatively low binding avidity and exhibit broad reactivity with B and T lymphocytes from most individuals.
## Abstract Twentyβone sera from 11 patients with systemic lupus erythematosus were titrated with ^125^Iβssβcalf thymus DNA to determine their maximum capacity to bind DNA. Only five sera were capable of binding > 90% of the input DNA. The remaining sixteen sera showed maximum DNA binding levels be
## Abstract To further clarify the clinical significance of nDNA antibodies in systemic lupus erythematosus, 70 patients were studied longitudinally over an average period of 3 years each. Serum hemolytic complement (CH50) and nDNA antibodies measured by antigen binding and complement fixation were