✦ LIBER ✦

The significance of clinical trials and the role of meta-analyses

✍ Scribed by Bartolucci, Al

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 45 KB
Volume: 72
Category: Article
ISSN: 0022-4790
DOI: 10.1002/(sici)1096-9098(199911)72:3<121::aid-jso2>3.0.co;2-s

No coin nor oath required. For personal study only.

✦ Synopsis

Much of the literature is turning attention to metaanalyses. This may be positive in light of the many underpowered studies that have been reported. However, one must step back and put this activity in perspective and not lose sight of the important role of the clinical trial in research.

Further elaboration on the meaning and role of metaanalysis will be forthcoming. First, it is appropriate to discuss or review the clinical trial. A clinical trial is a study designed to determine the safety and/or efficacy of a treatment or procedure. Safety is usually defined as toxicity or adverse event. Efficacy has many facets, such as response to therapy, response duration, survival, and quality of life. One may consider response as a change in

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